EB10; EH40.2; EH64; EC20.03; EC20.0Y; EC20.02
Grading & Level of Importance: B
Red man syndrome. Symptoms. Various diagnoses.
See specific diagnoses. See also chapter Red Face.
Inflammatory and scaly or exfoliative skin condition withredness and scaling of >90% of the skin, which either is primarily involved or spreads secondarily from a non-erythrodermic dermatosis.
Aetiology & Pathogenesis
Depends on underlying diagnosis (see classification).
Signs & Symptoms
Almost complete (>90%) redness and different degree of scaling of the skin, with or without itch. Sparing of the skin in the axila and abdominal folds or on the trunk (nappes claires). Swelling of lymph nodes as a consequence of pruritus scratching, erosions and superinfections. Due to loss of albumin and electrolytes via the exfoliative scaling edema develops. Sometimes temperature dysregulation and/or fever. Cachexia in some cases.
Total skin, according to definition.
- Sézary syndrome.
- Erythrodermic mycosis fungoides.
- Staphylococcal scalded skin syndrome (SSSS). Erythroderma due to secondary loss of function of the skin (deficiency of vitamins, electrolytes; malabsorption due to alcohol excess with exsiccation) Senile-(melano-) erythroderma (with cachexia).
- Congenital ichthyosiform erythroderma.
- Severe generalised sunburn.
- Ofuji Disease.
- Psoriatic erythroderma.
- Pityriasis rubra pilaris.
- Atopic eczema.
- Drug reaction.
- Generalised cutaneous mastocytosis.
- Generalised urticaria.
Laboratory & other workups
Depending on diagnosis (mostly full blood count, electrolytes, liver enzymes, lymphocyte sub-populations, histamine, IgE).
Depending on diagnosis.
Can be acute, sub-acute and chronic.
Loss of fluid (exsiccation), of proteins and electrolytes (scaling), cardiac insufficiency; thermal loss.
Redness and scaling of the total integument. Specific diagnosis of the underlying disorder is based on the dynamic and follow up of the dermatosis and the histologic features.
Prevention & Therapy
Depending on diagnosis. Because of emergency situations, there is often a necessity of an acute intervention.
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