Grading & Level of Importance: B
Herxheimer病
由布氏疏螺旋体慢性感染而导致的萎缩性皮肤病。
布氏疏螺旋体感染而产生的晚期表现。
一期：炎性-红斑阶段
二期：萎缩阶段（烟卷纸样皮肤, 毛细血管扩张, 色素改变）
硬化阶段（尺骨和胫骨处见带状硬皮病样胶原改变），纤维结节（大小数厘米，软骨样硬度的结节，分布在关节周围）。
手和足，开始单侧，之后为对称性。
血沉增快，抗螺旋体IgG抗体滴度增高。
以浆细胞为主的浸润。
软组织和肌肉的萎缩。
依据临床特点、组织病理和螺旋体血清学呈阳性反应。
一期与血栓静脉炎区别
二期与静脉曲张区别
所有期均与创伤后骨萎缩区别
多疗程抗生素治疗。
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