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致病因子为传染性软疣病毒（嗜表皮痘病毒），在人与人之间通过直接接触而传播，好发于儿童或性伴。
2.1.1 传染性软疣
Grading & Level of Importance: A
定义
症状
单发或多发性（假性Koebner 现象即因搔抓引起的线状自体接种）圆顶状丘疹，中心凹陷，通常为正常肤色，有玻璃样光泽，可略泛红或泛黄。
并发症
特应性皮炎或免疫抑制病人可合并软疣性湿疹（100个以上皮损）。
治疗
可用角质松解剂、刮除法和消毒剂。
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