Grading & Level of Importance: B
Chin He Liu, Zhengzhou
概述:
日光性角化病
由慢性日光暴露引起的原位癌。
人乳头瘤病毒(HPV)、遗传倾向、慢性长期紫外线照射和免疫力低下均与发病相关。
黄棕色或红色、局限性、角化过度性斑疹或斑片。
日光暴露部位(面部、手背部和前臂部)。
角化过度,表皮细胞排列紊乱,不典型性角质形成细胞和炎性浸润。
慢性病程。
可能恶变为鳞状细胞癌(每年5%)。
依据临床表现和组织病理。
鲍恩病、脂溢性角化病和早期鳞状细胞癌。
防晒,切除,冷冻,光动力治疗,5-氟尿嘧啶霜或者咪喹莫特霜剂,双氯芬酸钠和巨大戟醇甲基丁烯酸酯凝胶。
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